The human fovea is known for its distinctive pit‐like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces (...) acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta‐analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development. (shrink)

Philosophers and ethicists debate this controversial moral principle illustrating its application to current moral dilemmas such as war, suicide, nuclear power, affirmative action, and morphine use for terminal cancer patients.

Rhodopsin, upon activation by light, transduces the photon signal by activation of the G‐protein, transducin. The well‐studied rhodopsin/transducin system serves as a model for the understanding of signal transduction by the large class of G‐protein‐coupled receptors. The interactive form of rhodopsin, R*, is conformationally similar or identical to rhodopsin's photolysis intermediate Metarhodopsin II (MII). Formation of MII requires deprotonation of rhodopsin's protonated Schiff base which appears to facilitate some opening of the rhodopsin structure. This allows a change in conformation at (...) rhodopsin's cytoplasmic surface that provides binding sites for transducin. Rhodopsin's 2nd, 3rd and putative 4th cytoplasmic loops bind transducin at sites including transducin's 5 kDa carboxyl‐terminal region. Site‐specific mutagenesis of rhodopsin is being used to distinguish sites on rhodopsin's surface that are important in binding transducin from those that function in activating transducin. These observations are consistent with and extend studies on the action of other G‐protein‐coupled receptors and their interactions with their respective G proteins. (shrink)

Only in recent years have developmental psychologists begun advocating and exploring dual-process theories and their applicability to cognitive development. In this paper, a dual-process model of developments in two processing systems—an “analytic” and an “experiential” system—is discussed. We emphasise the importance of “metacognitive intercession” and developments in this ability to override experiential processing. In each of two studies of sunk cost decisions, age-related developments in normative decisions were observed, as were declines in the use of a “waste not” heuristic. In (...) the second study, children and adolescents were presented with arguments for normative and non-normative sunk cost decisions. Following argument evaluation, participants were re-presented the original problems and a set of novel, transfer problems. Results indicated that post-argument improvements were most apparent during adolescence. Age-related improvements were most noticeable on the transfer problems. In general, the findings suggest that the ability to metacognitively intercede (i.e., reflect on arguments; inhibit experientially produced responses) emerges towards middle adolescence. However, even by the end of adolescence, in the absence of significant contextual cues and motivation, this ability is infrequently utilised. (shrink)

In this article, I show how it is possible, working from a Thomistic perspective, to affirm the existence of animal rights. To start, I show how it is possible to ascribe indirect rights to animals—in particular, the indirect right to not be treated cruelly by us. Then, I show how it is possible to ascribe some direct rights to animals using the same reasoning that Aquinas offers in defending the claim that animals have indirect rights. Next, I draw on elements (...) of Aquinas’s metaphysical worldview in order to buttress the claim that animals have direct rights. I then respond to an attempt to ground the ethical treatment of animals, but not direct rights for animals, in natural law. In conclusion, I affirm that it is permissible to use animals to further the human good so long as in doing so we respect the direct rights that they possess. (shrink)

This volume presents a series of influential essays by Paul Boghossian on the theory of content and on its relation to the phenomenon of a priori knowledge. The essays are organized under four headings: the nature of content; content and self-knowledge; knowledge, content, and the a priori; and colour concepts.

In this article I offer an extended, critical review of the analytic theology project. In the first part of the article, I investigate the origins and rise of analytic theology. I also offer some initial insights into the nature of analytic theology, based on some of what its chief proponents understand analytic theology to be. In the second part of the article, I summarize and evaluate some of the major contributions that already have been made within analytic theology. In the (...) third and final section of the article, I evaluate the analytic theology project as a whole, testing its compatibility with certain methods and movements within the Christian theological tradition. Based on this discussion, I then begin to narrate the advantages of construing analytic theology more narrowly, as a dogmatic project committed to articulating and defending Christian doctrine in rational pursuit of genuine theological knowledge and truth. My final claim is that analytic theologians should continue to engage in bold, speculative inquiry into the nature of the divine as well as related divine matters, and thus remain committed to developing and defending theology as a dogmatic and speculative enterprise. By doing so, analytic theologians will help fortify and elevate the contemporary theological enterprise as a whole. (shrink)

This article briefly review the fundamentals of structural equation modeling for readers unfamiliar with the technique then goes on to offer a review of the Martin and Cullen paper. In summary, a number of fit indices reported by the authors reveal that the data do not fit their theoretical model and thus the conclusion of the authors that the model was “promising” are unwarranted.

This paper is the reprinting under a new title of the “Foreword” of Paul A. Weiss's Life, Order, and Understanding: A Theme in Three Variations, published in 1970 as volume 8 supplement of The Graduate Journal of the University of Texas (Austin, Texas, #5.00 [hardcover], #2.50 [paperback], 157 pages). We reprint this paper here for two reasons. The first is that its beautiful, scientifically grounded imagery of living systems in relation to wave dynamics provides a significant supplement to this (...) issue of Zygon on human values in the context of thermodynamics. The second is that it is hoped this foreword will serve better than would a book review to introduce Zygon readers to the philosophical and scientific wisdom contained in Life, Order, and Understanding.–Editor. (shrink)

This review essay examines the emergence of the patient narrative or “pathography” in the late eighteenth and early nineteenth century in relation to the great cultural, epistemological, and ethical transformations that enabled the formation of modern medicine. John Wiltshire’s book provides an historical overview of this complex process, as well as laying the basis for a contemporary critique of some of its key assumptions.

Reconciliation and the Technics of Healing Content Type Journal Article Pages 235-237 DOI 10.1007/s11673-011-9318-y Authors Paul A. Komesaroff, Monash Centre for Ethics in Medicine and Society, Monash University, Melbourne, Vic., Australia Elizabeth Kath, Global Cities Institute, RMIT University, Melbourne, Vic., Australia Paul James, Global Cities Institute, RMIT University, Melbourne, Vic., Australia Journal Journal of Bioethical Inquiry Online ISSN 1872-4353 Print ISSN 1176-7529 Journal Volume Volume 8 Journal Issue Volume 8, Number 3.

The Supreme Court decided Box v. Planned Parenthood of Indiana and Kentucky in 2019. Justice Clarence Thomas’s opinion in the case claimed there was a direct connection between the legalization of abortion, in the late 20th Century, and the beginnings of the birth control movement a full three quarters of a century earlier. “Many eugenicists,” Thomas argued, “supported legalizing abortion.”Justice Samuel Alito highlighted similar claims in Dobbs v. Jackson Women’s Health, citing a brief entitled “The Eugenic Era Lives on through (...) the Abortion Movement.” That brief was an echo of Justice Thomas’ misguided attempt at history in the Box opinion. Similar claims reoccur in Judge Matthew Kacsmaryk’s opinion in the Texas mifepristone case, Alliance for Hippocratic Medicine v. U.S. Food and Drug Administration.These false claims are the focus of this article. There is no evidence that early leaders of the eugenics movement supported abortion as part of the movement for birth control. It is accurate to describe those leaders as anti-abortion, and their followers as people who condemned abortion for moral, legal, and medical reasons. (shrink)

Following Oliver Ramsbotham’s observation that conflict resolution and analysis have not taken radical disagreement seriously enough, and in light of his lament that he has not yet found an adequate philosophy of radical disagreement, this article claims that the philosophy of Alasdair MacIntyre provides some coreelements of any adequate philosophy of radical disagreement. MacIntyre’s theory suggests that the problem of radical disagreement is in fact more radical thanRamsbotham affirms. Ramsbotham’s account of the strategic engagement of discourses (SED) approach is critiqued (...) in light of MacIntyre’s diagnosis of radical disagreement, which calls into question its theoretical and philosophical basis. The main problem is held to be that of internal radical disagreement, which SED appears to skirt over. This is elucidated through a brief exploration of two philosophical approaches to moral-political disagreement in relation to Israeli peace activism and the Colombian conflict. (shrink)

W. V. Quine was the most important naturalistic philosopher of the twentieth century and a major impetus for the recent resurgence of the view that empirical science is our best avenue to knowledge. His views, however, have not been well understood. Critics charge that Quine’s naturalized epistemology is circular and that it cannot be normative. Yet, such criticisms stem from a cluster of fundamental traditional assumptions regarding language, theory, and the knowing subject – the very presuppositions that Quine is at (...) pains to reject. Through investigation of Quine’s views regarding language, knowledge, and reality, the author offers a new interpretation of Quine’s naturalism. The naturalism/antinaturalism debate can be advanced only by acknowledging and critiquing the substantial theoretical commitments implicit in the traditional view. Gregory argues that the responses to the circularity and non-normativity objections do just that. His analysis further reveals that Quine’s departure from the tradition penetrates the conception of the knowing subject, and he thus offers a new and engaging defence of Quine’s naturalism. (shrink)

The Universe is One places the ancient synthesis of Stoicism, Platonism, Judaism, and Christianity in active dialogue with modern process science in order to conjoin science, philosophy, and theology into the human quest for meaning. Paul A. Olivier proposes a comprehensive theory of knowledge, which he expands into a theory of life, correlating modern process science and the western-Judeo-Christian heritage into a grand theory of the Universe. He brings together the ideas of influential thinkers from the world of science (...) with those from the world of New Testament studies. Olivier clearly explains concepts from diverse fields to construct a satisfying theory of knowledge and life. He accomplishes this through an examination of the dominance of polarity in all aspects of the universe, such as chaos and order, predictability and unpredictability. Through this complex blend of opposites Olivier develops his theory as an interaction of Word and Spirit that provides the Universe with everything necessary to account for its creation and ongoing evolution. The Universe continually creates and sustains itself out of its own internal necessity coupled paradoxically with the fluidity of its own inherent unpredictability. (shrink)

Originally published in 1986. This work remains of compelling interest to those concerned with the natural sciences and their social problems. It puts forward original and unorthodox ideas about the philosophy of and sociology of science, starting from the conviction that modern societies face deep problems arising from unresolved dilemmas about the meaning, content and technical applications of the theories of nature they employ. The book draws on insights developed within a variety of traditions to explore these problems, especially the (...) work of Edmund Husserl and modern critical theory. (shrink)

The focus of discussion about the ethical issues associated with the COVID-19 pandemic has been on the great suffering to which it has given rise. However, there may be some unexpected positive outcomes that also emerge from the global disaster. The rupturing of entrenched systems and processes, the challenging of certainties that seemed beyond question, and the disruption of the assumed consensus of modernity may contribute to a rediscovery of the challenges that compose an ethical life. Elements of such a (...) process are evident in the surge of community support and mutual caring, of spontaneous acts of joyous solidarity, of suspension of past conflicts, and exploration of new forms of reconciliation. The experiences are tentative and the outcomes uncertain, but at least for a moment the hope of a new way forward has been raised. (shrink)

I argue that Giorgio Agamben employs two, contradictory theories of the state in his works. Earlier works, such as "The Coming Community" and "Means without End", suggest that the state today functions as an aspect of the society of the spectacle where spectacle is the logical extension of the commodity form under late capitalism. This part of Agamben's work attributes a determined character to the state and a determining power to the economic forces of capitalism that conditions particular forms of (...) the state. Later work, such as "Homo Sacer: Sovereign Power and Bare Life" and " State of Exception", are preoccupied with the logic of juridical sovereignty and the increased frequency of states of emergency. This part of Agamben's work attributes a determining strength to the state under current conditions. Although his earlier work provides a more coherent narrative of how it is possible to move from contemporary society to ideal community, it does not provide the theory of political action necessary to overcome the power of the state he describes when he theorizes the state in "Homo Sacer" and " State of Exception". None of the three possibilities of political action present in his later works provides passage beyond state sovereignty without violating his philosophical commitments. (shrink)

Compatibilism combines an externalist view of mental content with a doctrine of privileged self‐knowledge. The essay presents a reductio of compatibilism by arguing that if compatibilism were true, we would be in a position to know certain facts about the world a priori, facts that no one can reasonably believe are knowable a priori. Whether this should be taken to cast doubt on externalism or privileged self‐knowledge is not discussed. Consideration is given to the ’empty case’—the case in which a (...) thinker expresses what he takes to be a genuine thought concerning a natural kind but where there is in fact no relevant natural kind, so that the putative natural kind term fails to refer. It is argued that, in such a case, on an externalist conception of natural kind terms, the thinker is deluded in taking himself to be expressing a complete thought, and that such delusions are not compatible with privileged self‐knowledge. (shrink)

L'étude de la communication peut offrir une perspective sur le contexte de la théologie, un examen de sa structure, et une reflexion sur son contenu. La communication est primordiale pour la société contemporaine, affectant la façon dont les gens utilisent leur temps, façonnant les informations qu'ils reçoivent, influençant la manière dont ils pensent , et les rendant plus soupçonneux vis à vis de l'autorité. L'histoire de la théologie montre les effets des formes de communication, reflétant la narration, la rhétorique, et (...) les structures polémiques des cultures orales, aussi bien que les instruments analytiques de l'écriture et l'imprimerie. Finalement, l'étude de la communication suggère une façon différente de considérer des sujets théologiques traditionnels. Le salut divin, par exemple, peut se concentrer sur la communication en interprètant l'histoire du salut comme une histoire de l'auto-communication de Dieu et la restauration de la communication humaine. (shrink)

This book offers an approach to Christian ethics. It does so first by organizing Christian ethics around the virtue of practical wisdom and suggesting what the guiding vision of a Christian practical wisdom should be. Second, it provides an account of practical wisdom that integrates literature drawn from the fields of philosophy, psychology, evolutionary theory, and the neurosciences. Reconceptualizing Christian ethics in this way can help us address-but not resolve once and for all-in a faithful way the challenges of our (...) divided age. (shrink)

The 'Phillips curve' represents the inverse relationship between inflation & unemployment, & is a central concept in macroeconomic analysis. This volume offers an assessment of how more sophisticated analysis of prices & wage setting & inflation expectations have changed the nature of the curve.

Dual-process theories of conditional reasoning predict that relationships among four basic logical forms, and to intellectual ability and thinking predictions, are most evident when conflict arises between experiential and analytic processing (e.g., Stanovich & West, 2000). To test these predictions, 210 undergraduates were presented with conditionals for which the consequents were either weakly or strongly associated with alternative antecedents (i.e., WA and SA problems, respectively). Consistent with predictions, modus ponens inferences were not related to inferences on the uncertain forms (affirmation (...) of the consequent, denial of the antecedent). On WA problems, modus tollens, affirmation of the consequent, and denial of the antecedent were related to each other and to verbal ability. Modus ponens was linked to verbal ability only when disabling conditions were activated. In accord with the predictions of Stanovich and West (2000), on most problems, thinking dispositions predicted variance in inferences independently from verbal ability. We argue that a largely automatic experiential processing system governs performance on modus ponens, unless disablers are activated. Consciously controlled analytic processing predominates on the uncertain forms and, under some conditions, on modus tollens. (shrink)

Two major reports in the UK and USA have recently sanctioned as ethically acceptable genome editing of future generations for the treatment of serious rare inherited conditions. This marks an important turning point in the application of recombinant DNA techniques to humans. The central question this paper addresses is how did it became possible for human genetic engineering (HGE) of future generations to move from an illegitimate idea associated with eugenics in the 1980s to a concrete proposal sanctioned by scientists (...) and bioethicists in 2020? The paper uses the concept of a regime of normativity to understand the co-evolution and mutual shaping of technology, imaginaries, norms and governance processes in debates about HGE in the USA and UK. It will be argued that interlinked discursive, institutional, political and technological changes have made proposals for the use of genome editing in the genetic engineering of future generations both “thinkable” and legitimate. (shrink)

It is very common these days to come across the claim that the notions of mental content and linguistic meaning are normative notions. In the work of many philosophers, it plays a pivotal role. Saul Kripke made it the centerpiece of his influential discussion of Wittgenstein’s treatment of rulefollowing and private language; he used it to argue that the notions of meaning and content cannot be understood in naturalistic terms. Kripke’s formulations tend to be in terms of the notion of (...) linguistic meaning, but his argumentative strategy makes it clear that he holds both versions of the claim.... (shrink)